LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation
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چکیده
منابع مشابه
TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice
SHARPIN regulates immune signaling and contributes to full transcriptional activity and prevention of cell death in response to TNF in vitro. The inactivating mouse Sharpin cpdm mutation causes TNF-dependent multi-organ inflammation, characterized by dermatitis, liver inflammation, splenomegaly, and loss of Peyer's patches. TNF-dependent cell death has been proposed to cause the inflammatory ph...
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ژورنال
عنوان ژورنال: Cell Metabolism
سال: 2019
ISSN: 1550-4131
DOI: 10.1016/j.cmet.2019.02.014